EVIDENCE FOR RETROTRANSCRIPTION OF PROTEIN-CODING GENES IN THE DROSOPHILA-SUBOBSCURA GENOME

被引：20

作者：

MARFANY, G ^{[1
]}

GONZALEZDUARTE, R ^{[1
]}

机构：

[1] UNIV BARCELONA,FAC BIOL,DEPT GENET,AVDA DIAGONAL 645,E-08028 BARCELONA,SPAIN

来源：

JOURNAL OF MOLECULAR EVOLUTION | 1992年 / 35卷 / 06期

关键词：

DROSOPHILA-SUBOBSCURA; ADH; RETROSEQUENCE; RETROPSEUDOGENE; REPETITIVE DNA; EVOLUTIONARY PATTERNS;

D O I：

10.1007/BF00160210

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evidence is provided for the presence of retrosequences (also named retroposons) arising from Adh in the Drosophila subobscura genome. Restriction analysis and primary structure of two different retrosequence-containing clones, S812 and S135, are reported. The fact that these retrosequences lack introns and a recognizable promoter strongly supports their retrotranscriptional origin. Adjacent to the two retrosequences analyzed, a middle repetitive DNA element has been found which bears no clear similarity to any sequence reported to date in the GenBank/EMBL Data Library. A comparative analysis of these retrosequences with the functional Adh gene of D. subobscura is presented. In addition, a model concerning the origin, functionality, and propagation of these genome elements is discussed.

引用

页码：492 / 501

页数：10

共 41 条

[1] ZFA IS AN EXPRESSED RETROPOSON DERIVED FROM AN ALTERNATIVE TRANSCRIPT OF THE ZFX GENE [J].