In vitro and in vivo experimental studies on single crystal sapphire dental implants

被引:17
作者
Arvidson, K. [1 ,2 ]
Fartash, B. [1 ,2 ]
Moberg, L-E. [1 ,2 ]
Grafstrom, R. [3 ]
Ericsson, I. [4 ]
机构
[1] Karolinska Inst, Dept Prosthet Dent, Fac Odontol, Huddinge Hosp, S-14104 Huddinge, Sweden
[2] Karolinska Inst, Dept Clin Res Ctr, Huddinge Hosp, S-14104 Huddinge, Sweden
[3] Karolinska Inst, Dept Toxicol, S-10401 Stockholm, Sweden
[4] Univ Gothenburg, Dept Periodontol, Gothenburg, Sweden
关键词
cell culture; dissolution; epithelial cells; fibroblasts; rat implantology; light microscopy; scanning electron microscopy;
D O I
10.1034/j.1600-0501.1991.020201.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Successful attachment of the oral tissues to an endosseous dental implant relies in part on its chemical stability, nontoxic properties and maintenance of normal cell functions in the surrounding tissues. The aim of this study was therefore to investigate these 3 factors experimentally. The corrosion resistance of single crystal sapphire (alpha-Al(2)O(3)) implants was analysed with respect to the release of aluminium ions; no ions could be detected in the test solutions. The influence of single crystal sapphire on the behaviour of human epithelial cells and fibroblasts derived from biopsies of the oral mucosa, was studies. The cells were cultured in chemically defined or in low serum-containing media. compared to the corresponding control cultures, no effects on cell morphology and growth characteristics were observed. Sapphire rods were inserted subcutaneously into rats and tissue responses were examined after 4, 8, and 12 weeks post-implantation. None or slight reactions were found in the tissues. The combined evaluation of these experimental approaches indicates that single crystal sapphire is a material well suited for biological implantation.
引用
收藏
页码:47 / 55
页数:9
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