PARVALBUMIN-IMMUNOREACTIVE DYSTROPHIC NEURITES AND ABERRANT SPROUTS IN THE CEREBRAL-CORTEX OF PATIENTS WITH ALZHEIMERS-DISEASE

被引：16

作者：

FERRER, I

ZUJAR, MJ

RIVERA, R

SORIA, M

VIDAL, A

CASAS, R

机构：

[1] Unidad de Neuropatología, Servicio Anatomía Patológica, Hospital Príncipes de España, Universidad de Barcelona, Hospitalet de Llobregat

来源：

NEUROSCIENCE LETTERS | 1993年 / 158卷 / 02期

关键词：

CEREBRAL CORTEX; BASKET CELL; AXO-AXONIC NEURON; ALZHEIMERS DISEASE; PARVALBUMIN;

D O I：

10.1016/0304-3940(93)90254-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parvalbumin-immunoreactive dystrophic neurites and aberrant terminal sprouts associated with senile plaques, together with preserved density of parvalbumin-immunoreactive neurons, were found in the cerebral cortex of two patients with Alzheimer's disease, one of them familiar, in which a biopsy of the left frontal lobe was carried out for diagnostic and counselling purposes. These findings suggest that, although parvalbumin-immunoreactive cells are relatively resistant to degeneration in Alzheimer's disease, parvalbumin-immunoreactive neuronal processes can degenerate in some cases of Alzheimer's disease.

引用

页码：163 / 166

页数：4

共 20 条

[1] DIFFERENTIAL DISTRIBUTION OF PARVALBUMIN-IMMUNOREACTIVE PERICELLULAR CLUSTERS OF TERMINAL BOUTONS IN DEVELOPING AND ADULT MONKEY NEOCORTEX [J].

AKIL, M ;

LEWIS, DA .

EXPERIMENTAL NEUROLOGY, 1992, 115 (02) :239-249

[2] CALCIUM-BINDING PROTEINS - SELECTIVE MARKERS OF NERVE-CELLS [J].

ANDRESSEN, C ;

BLUMCKE, I ;

CELIO, MR .

CELL AND TISSUE RESEARCH, 1993, 271 (02) :181-208

[3] LOSS OF PARVALBUMIN-IMMUNOREACTIVE NEURONS FROM CORTEX IN ALZHEIMER-TYPE DEMENTIA [J].

ARAI, H ;

EMSON, PC ;

MOUNTJOY, CQ ;

CARASSCO, LH ;

HEIZMANN, CW .

BRAIN RESEARCH, 1987, 418 (01) :164-169

[4] SUBSTANCE-P AND SOMATOSTATIN COEXIST WITHIN NEURITIC PLAQUES - IMPLICATIONS FOR THE PATHOGENESIS OF ALZHEIMERS-DISEASE [J].

ARMSTRONG, DM ;

BENZING, WC ;

EVANS, J ;

TERRY, RD ;

SHIELDS, D ;

HANSEN, LA .

NEUROSCIENCE, 1989, 31 (03) :663-671

[5] CORTICAL-NEURONS IMMUNOREACTIVE WITH ANTISERA AGAINST NEUROPEPTIDE-Y ARE ALTERED IN ALZHEIMERS-TYPE DEMENTIA .2. [J].

CHANPALAY, V ;

LANG, W ;

ALLEN, YS ;

HAESLER, U ;

POLAK, JM .

JOURNAL OF COMPARATIVE NEUROLOGY, 1985, 238 (04) :390-400

[6] VISUALIZATION OF CHANDELIER CELL AXONS BY PARVALBUMIN IMMUNOREACTIVITY IN MONKEY CEREBRAL-CORTEX [J].

DEFELIPE, J ;

HENDRY, SHC ;

JONES, EG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (06) :2093-2097

[7]

DEMEULEMEESTER H, 1991, EXP BRAIN RES, V84, P538

[8] PARVALBUMIN IMMUNOREACTIVE NEURONS IN NORMAL HUMAN TEMPORAL NEOCORTEX AND IN PATIENTS WITH ALZHEIMERS-DISEASE [J].

FERRER, I ;

SORIANO, E ;

TUNON, T ;

FONSECA, M ;

GUIONNET, N .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1991, 106 (02) :135-141

[9] GROWTH OF ABNORMAL NEURITES IN ATYPICAL ALZHEIMERS-DISEASE - A STUDY WITH THE GOLGI METHOD [J].

FERRER, I ;

AYMAMI, A ;

ROVIRA, A ;

VECIANA, JMG .

ACTA NEUROPATHOLOGICA, 1983, 59 (03) :167-170

[10]

FONSECA M, IN PRESS NEUROSCIENC

← 1 2 →