SURFACTANT EFFECTS IN PERCUTANEOUS-ABSORPTION .2. EFFECTS ON PROTEIN AND LIPID STRUCTURE OF THE STRATUM-CORNEUM

被引：19

作者：

ASHTON, P

WALTERS, KA

BRAIN, KR

HADGRAFT, J

机构：

[1] WELSH NATL SCH MED,REDWOOD BLDG,KING EDWARD VII AVE,CARDIFF CF1 3XF,WALES

[2] AN-EX LTD,CARDIFF CF1 3XF,WALES

[3] UNIV KENTUCKY,DEPT OPHTHALMOL,LEXINGTON,KY 40536

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 87卷 / 1-3期

关键词：

LIPID STRUCTURE; STRATUM-CORNEUM; PENETRATION ENHANCER; DSC; KERATIN; BIREFRINGENCE;

D O I：

10.1016/0378-5173(92)90252-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of several known penetration enhancers on the lipid structure of human stratum corneum have been investigated by differential scanning calorimetry. Effects on the birefringence were also examined. A correlation was found to exist between the ability of a compound to increase the birefringence of the stratum corneum and its reported tendency to induce local irritation when applied to the skin.

引用

页码：265 / 269

页数：5

共 20 条

[1]

BARRY BW, 1986, J PHARM PHARMACOL, V37, pP71

[2] INTERACTIONS BETWEEN COMPONENTS IN BIOLOGICAL-MEMBRANES AND THEIR IMPLICATIONS FOR MEMBRANE-FUNCTION [J].