REDUCTION OF TUMOR-NECROSIS-FACTOR PRODUCTION BY SPLENOCYTES FROM V-HA-RAS ONCOGENE-BEARING MICE

被引：5

作者：

CHEN, GJ ^{[1
]}

COLOMBO, LL ^{[1
]}

LOPEZ, MC ^{[1
]}

WATSON, RR ^{[1
]}

机构：

[1] UNIV ARIZONA,DEPT FAMILY & COMMUNITY MED,TUCSON,AZ 85624

来源：

CANCER LETTERS | 1993年 / 74卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ONCOMOUSE; TUMOR NECROSIS FACTOR; GAMMA-INTERFERON; V-HA-RAS ONCOGENE;

D O I：

10.1016/0304-3835(93)90236-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mice containing the activated v-Ha-ras oncogene driven by the mouse mammary tumor virus promoter/enhancer produced less tumor necrosis factor (TNF) than genetically identical animals without it. Inbred Oncomice containing the v-Ha-ras oncogene and inbred FVB mice without it were grown for 6 months. Splenocytes were isolated and stimulated in vitro to produce tumor necrosis factor (TNF) and gamma-interferon (IFN). TNF production by cells from Oncomice was significantly decreased compared to cells from FBV mice. There was a tendency for decrease, but no significant difference was seen on IFN release. These observations suggest that the oncogene may play a role in the immune system.

引用

页码：147 / 150

页数：4

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