APPROACHES TO VECTOR CONTROL - NEW AND TRUSTED .2. MOLECULAR TARGETS IN THE INSECT MIDGUT

被引:13
作者
BILLINGSLEY, PF
机构
[1] Molecular and Cellular Parasitology Research Group, Department of Biology, Imperial College of Science and Technology and Medicine, London, SW7 2BB, Prince Consort Road
关键词
D O I
10.1016/0035-9203(94)90265-8
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The midgut of blood-feeding insects is an important site for the activity of antibodies and drugs ingested with the blood meal. These agents can be directed at molecular targets in the midgut, and may affect the insect directly by reducing its fitness, or indirectly by blocking transmission of a disease organism to the vector. Both of these result in eventual disease control. Immunization with crude vector or parasite preparations can result in isolation of vaccine candidates which are very effective but often of unknown function. Conversely, by examining carefully the vector's biology and its interaction with the parasite, it is possible to identify various physiological or cellular systems and vector-parasite interactions that can be interfered with. Examples of both approaches are presented in this paper. Anti-vector vaccines offer tremendous potential for disease control, as they can affect the parasite reproductive rate in a number of ways-reducing vector longevity, fecundity or competence. This is most striking if life expectancy of the vector is reduced to a period less than the extrinsic life cycle of the parasite. The rationale often presented for examining molecular systems in vectors is their control potential; it is clearly appropriate to re-examine many of these systems and realistically assess their applicability.
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页码:136 / 140
页数:5
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