ATTENUATED LIVE CHOLERA VACCINE STRAIN CVD-103-HGR ELICITS SIGNIFICANTLY HIGHER SERUM VIBRIOCIDAL ANTIBODY-TITERS IN PERSONS OF BLOOD-GROUP-O

被引：43

作者：

LAGOS, R

AVENDANO, A

PRADO, V

HORWITZ, I

WASSERMAN, S

LOSONSKY, G

CRYZ, S

KAPER, JB

LEVINE, MM

机构：

[1] UNIV CHILE, CTR VACUNAS DESAROLLO, SANTIAGO, 21201, CHILE

[2] UNIV CHILE, SERV SALUD METROPOL NORTE, CH-3001 SANTIAGO, CHILE

[3] UNIV MARYLAND, SCH MED, CTR VACCINE DEV, BALTIMORE, MD USA

[4] SWISS SERUM & VACCINE INST, BERN, SWITZERLAND

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 02期

关键词：

D O I：

10.1128/IAI.63.2.707-709.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Persons of blood group O are at increased risk of developing cholera gravis. In a randomized, placebo-controlled, double-blind safety-immunogenicity trial of live oral cholera vaccine CVD 103-HgR in 5- to 9-year-old Chilean children, vibriocidal antibody seroconversion (74% overall) did not differ by blood group. However, the reciprocal geometric mean titer (GMT) in blood group O vaccinees (GMT = 486) was higher than that in non-O vaccines (GMT = 179) (P < 0.02).

引用

收藏

页码：707 / 709

页数：3

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