Hyperhomocysteinemia and Endothelial Dysfunction

被引：93

作者：

Cheng, Zhong-Jian ^{[1
]}

Yang, Xiaofeng ^{[1
]}

Wang, Hong ^{[1
]}

机构：

[1] Temple Univ, Sch Med, Dept Pharmacol, 3420 North Broad St, Philadelphia, PA 19140 USA

来源：

CURRENT HYPERTENSION REVIEWS | 2009年 / 5卷 / 02期

关键词：

Hyperhomocysteinemia; endothelial dysfunction; vascular relaxation/vascular contractile responses;

D O I：

10.2174/157340209788166940

中图分类号：

R6 [外科学];

学科分类号：

1002 [临床医学]; 100210 [外科学];

摘要：

Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for cardiovascular diseases. Endothelial dysfunction (ED) is the earliest indicator of atherosclerosis and vascular diseases. We and others have shown that HHcy induced ED in human and in animal models of HHcy induced by either high-methionine load or genetic deficiency. Six mechanisms have been suggested explaining HHcy-induced ED. These include 1) nitric oxide inhibition, 2) prostanoids regulation, 3) endothelium-derived hyperpolarizing factors suppression, 4) angiotensin II receptor-1 activation, 5) endothelin-1 induction, and 6) oxidative stress. The goal of this review is to elaborate these mechanisms and to discuss biological and molecular events related to HHcy-induced ED.

引用

页码：158 / 165

页数：8

共 69 条

[1]

Endothelium as an organ system [J].

Aird, WC .

CRITICAL CARE MEDICINE, 2004, 32 (05) :S271-S279

[2]

5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels - Effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling [J].

Antoniades, Charalambos ;

Shirodaria, Cheerag ;

Warrick, Nicholas ;

Cai, Shijie ;

de Bono, Joseph ;

Lee, Justin ;

Leeson, Paul ;

Neubauer, Stefan ;

Ratnatunga, Chandi ;

Pillai, Ravi ;

Refsum, Helga ;

Channon, Keith M. .

CIRCULATION, 2006, 114 (11) :1193-1201

[3]

Flow-induced constriction in arterioles of hyperhomocysteinemic rats is due to impaired nitric oxide and enhanced thromboxane A2 mediation [J].

Bagi, Z ;

Ungvari, Z ;

Szollár, L ;

Koller, A .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (02) :233-237

[4]

Chronic methionine load-induced hyperhomocysteinemia enhances rat carotid responsiveness for angiotensin II [J].

Bonaventura, D ;

Tirapelli, CR ;

Haddad, R ;

Höehr, NF ;

Eberlin, MN ;

de Oliveira, AM .

PHARMACOLOGY, 2004, 70 (02) :91-99

[5]

A QUANTITATIVE ASSESSMENT OF PLASMA HOMOCYSTEINE AS A RISK FACTOR FOR VASCULAR-DISEASE - PROBABLE BENEFITS OF INCREASING FOLIC-ACID INTAKES [J].

BOUSHEY, CJ ;

BERESFORD, SAA ;

OMENN, GS ;

MOTULSKY, AG .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (13) :1049-1057

[6]

EDHF:: bringing the concepts together [J].

Busse, R ;

Edwards, G ;

Félétou, M ;

Fleming, I ;

Vanhoutte, PM ;

Weston, AH .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2002, 23 (08) :374-380

[7]

Improved vascular endothelial function after oral B vitamins - An effect mediated through reduced concentrations of free plasma homocysteine [J].

Chambers, JC ;

Ueland, PM ;

Obeid, OA ;

Wrigley, J ;

Refsum, H ;

Kooner, JS .

CIRCULATION, 2000, 102 (20) :2479-2483

[8]

Crucial role of extracellular signal-regulated kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat cardiac fibroblasts [J].

Cheng, CM ;

Hong, HJ ;

Liu, JC ;

Shih, NL ;

Juan, SH ;

Loh, SH ;

Chan, P ;

Chen, JJ ;

Cheng, TH .

MOLECULAR PHARMACOLOGY, 2003, 63 (05) :1002-1011

[9]

Endothelial dysfunction and salt-sensitive hypertension in spontaneously diabetic Goto-Kakizaki rats [J].

Cheng, ZJ ;

Vaskonen, T ;

Tikkanen, I ;

Nurminen, K ;

Ruskoaho, H ;

Vapaatalo, H ;

Muller, D ;

Park, JK ;

Luft, FC ;

Mervaala, EMA .

HYPERTENSION, 2001, 37 (02) :433-439

[10]

Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials [J].

Clarke, R ;

Frost, C ;

Sherliker, P ;

Lewington, S ;

Collins, R ;

Brattstrom, L ;

Brouwer, I ;

van Dusseldorp, M ;

Steegers-Theunissen, RPM ;

Cuskelly, G ;

Ward, M ;

McNulty, H ;

Scott, J ;

den Heijer, M ;

Blom, H ;

van der Put, N ;

Shorah, CJ ;

Malinow, MR ;

McMahon, M ;

Tobert, J ;

Kush, D ;

Joosten, E ;

Riezier, R ;

Pietrzik, K ;

Dierkes, J ;

Bronstrup, A ;

Jacques, P ;

Mason, J ;

Rosenberg, I ;

Thambyrajah, J ;

Landray, M ;

Townend, J ;

Wheeler, D ;

Ubbink, J ;

van Oort, F ;

Melse-Boonstra, A ;

Verhoef, P ;

Woodside, JV ;

Yarnell, J ;

Young, IS ;

Evans, AE ;

Wald, D ;

Law, M ;

Wald, N .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2005, 82 (04) :806-812

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