ON MECHANISM OF RADIATION-INDUCED INACTIVATION OF LYSOZYME IN DILUTE AQUEOUS SOLUTION

被引：135

作者：

ADAMS, GE

WILLSON, RL

ALDRICH, JE

CUNDALL, RB

机构：

[1] British Empire Cancer Campaign for Research, Research Unit in Radiobiology, Mount Vernon Hospital, Northwood, Middlesex

[2] Department of Chemistry, The University of Nottingham

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE | 1969年 / 16卷 / 04期

关键词：

D O I：

10.1080/09553006914551361

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

Combined pulse-radiolysis and enzyme-activity studies have shown that the radiation-induced inactivation of lysozyme in neutral aqueous solution is due principally to the reaction of hydroxyl radicals with tryptophan residues. Unlike some typical OH-radical scavengers which protect against inactivation, the thiocyanate ion (CNS)2- does not. This is due to a specific reaction between the thiocyanate radical and tryptophan residues. Part of this inactivating process involves tryptophan at position 108. © 1969 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：333 / &

共 21 条

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