OXANDROLONE FOR DELAYED PUBERTY IN BOYS TAKING LONG-TERM STEROID-THERAPY FOR RENAL-DISEASE

被引：4

作者：

REES, L

GREENE, SA

RIGDEN, SPA

HAYCOCK, GB

CHANTLER, C

PREECE, MA

机构：

[1] Division of Paediatrics, United Medical and Dental Schools of Guy's and St Thomas' Hospitals, Guy's Hospital, London

[2] Department of Growth and Development, Institute of Child Health, London, WC, Guildford Street

来源：

PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 02期

关键词：

Cyclosporin A; Oxandrolone; Pubertal delay; Renal transplantation; Steroid therapy; Steroid-sensitive nephrotic syndrome;

D O I：

10.1007/BF00858829

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Eleven boys, mean age 15.3 years (range 13.2-17.5), with pubertal delay in association with steroid therapy for steroid-sensitive nephrotic syndrome and following renal transplantation were treated with oxandrolone 2.5 mg daily for a mean of 0.50 years (range 0.34-0.61). Mean growth velocity increased from 3.9 cm/year (range 1.1-6.3) to 6.1 cm/year (range 2.0-14.4) and was maintained at 6.1 cm/year (range 0.4-10.2) (P<0.05). However, there was no significant difference in growth between the treated boys and age- and puberty-matched controls. Elevation of blood cyclosporin A and creatinine levels occurred in the transplant patients. Oxandrolone may initiate a pubertal growth spurt in patients taking steroid therapy for renal disease, but should be used with extreme caution because of potential side-effects. © 1990 IPNA.

引用

页码：160 / 162

页数：3

共 7 条

[1]

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[2]

Rees L., Greene S.A., Adlard P., Jones J., Haycock G.B., Rigden S.P.A., Preece M., Chantler C., Growth and endocrine function in children following renal transplantation, Arch Dis Child, 63, pp. 1326-1332, (1988)

[3]

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[4]

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[5]

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[6]

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[7]

Jones R.W.A., El Bishti M.M., Bloom S.R., Burke J., Carter J.E., Counahan R., Dalton R.N., Morris M.C., Chantler C., The effects of anabolic steroids on growth, body composition and metabolism in boys with chronic renal failure on regular hemodialysis, J Pediatr, 97, pp. 559-566, (1980)

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