MUTAGENICITY OF AMINOPHENYL AND NITROPHENYL ETHERS, SULFIDES, AND DISULFIDES

被引:45
作者
LAVOIE, E
TULLEY, L
FOW, E
HOFFMANN, D
机构
[1] Division of Environmental Carcinogenesis, Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla
来源
MUTATION RESEARCH | 1979年 / 67卷 / 02期
关键词
D O I
10.1016/0165-1218(79)90123-X
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The mutagenic activity of several aromatic amines and aromatic nitro compounds related to 4,4′-methylenedianiline towards Salmonella typhymurium tester strains TA100 and TA98 was evaluated. The heteroatomic analogs of 4,4′-methylenedianiline which include aminophenyl and nitrophenyl ethers, sulfides and disulfides were assayed in the presence of rat-liver homogenate. The relative mutagenic response of these analogs indicated the following order of activity, S > O > CH2CH2 {slanted equal to or greater-than} SS. In both tester strains 4-aminophenylsulfone was inactive with and without microsomal activation. The p-nitrophenyl ethers, sulfides and disulfides were relatively strong mutagens without microsomal activation towards TA100. While 4-nitrophenyldisulfide was found to possess significantly different mutagenic activity than 4-nitrothiophenol in TA98, 4-aminophenyl disulfide has similar mutagenic properties to 4-aminothiophenol in both tester strains TA100 and TA98. © 1979.
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页码:123 / 131
页数:9
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