EFFECTS OF TEMPERATURE AND FLOW-RATE ON REGIONAL BLOOD-FLOW AND METABOLISM DURING CARDIOPULMONARY BYPASS

被引：55

作者：

LAZENBY, WD ^{[1
]}

KO, W ^{[1
]}

ZELANO, JA ^{[1
]}

LEBOWITZ, N ^{[1
]}

SHIN, YT ^{[1
]}

ISOM, OW ^{[1
]}

KRIEGER, KH ^{[1
]}

机构：

[1] CORNELL UNIV,MED CTR,NEW YORK HOSP,DIV CARDIAC SURG,DIV CARDIOTHORAC SURG,ROOM F2108,NEW YORK,NY 10021

来源：

ANNALS OF THORACIC SURGERY | 1992年 / 53卷 / 06期

关键词：

D O I：

10.1016/0003-4975(92)90367-D

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Eleven dogs were subjected to a 150-minute period of cardiopulmonary bypass that consisted of a high-flow, normothermic phase, a high-flow, hypothermic phase, a low-flow, hypothermic phase, and then a high-flow, rewarming phase. Regional blood flow and oxygen consumption to the brain, intestines, kidney, and hind limb were determined at baseline and at 10-minute intervals during cardiopulmonary bypass. Blood flow to the carotid artery, superior mesenteric artery, and renal artery declined significantly with hypothermic cardiopulmonary bypass whereas blood flow to the femoral artery increased significantly. Although total body oxygen consumption returned to baseline values at the end of the rewarming phase, oxygen consumption for these regions differed somewhat from their baseline values. We conclude that blood flow during hypothermic cardiopulmonary bypass is shunted to skeletal muscle, particularly with high pump flows. Additionally, the return of total body oxygen consumption to baseline after rewarming is not necessarily reflected at the regional level.

引用

页码：957 / 964

页数：8

共 27 条

[1] ANAEROBIC METABOLISM AND METABOLIC ACIDOSIS DURING CARDIOPULMONARY BYPASS [J].