RESUMPTION OF PITUITARY AND OVARIAN ACTIVITY POSTPARTUM - ENDOCRINE AND ULTRASONIC OBSERVATIONS IN BROMOCRIPTINE-TREATED WOMEN

被引：1

作者：

HAARTSEN, JE

HEINEMAN, MJ

ELINGS, M

EVERS, JLH

LANCRANJAN, I

机构：

[1] Department of Obstetrics and Gynaecology, De Wever Hospital, 6401 CX Heerlen

[2] Department of Obstetrics and Gynaecology, Academisch Ziekenhuis Maastricht

[3] Department of Neuroendocrinology, Clinical Research, Sandoz Pharma Ltd, CH-4OO2 Basel

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 06期

关键词：

OVARIAN ACTIVITY; POSTPARTUM; ULTRASONIC OVULATION DETECTION;

D O I：

10.1093/oxfordjournals.humrep.a137730

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The resumption of pituitary and ovarian activity was investigated by hormonal measurements and ultrasound scanning in 45 healthy post-partum women who were treated with bromocriptine. Bromocriptine, 50 mg (Parlodel LAR) was administered within 24 h post-partum. Plasma luteinizing hormone, follicle stimulating hormone, oestradiol, progesterone and prolactin concentrations were measured repeatedly and correlated with ultrasound measurements. Forty-one of the 45 women completed the study. A prompt fall in prolactin levels to normal (non-pregnant) values was observed within 24 h post-partum. Hereafter, a rapid return of the normal menstrual cycle was observed. Endocrine evidence of ovulation was obtained in 19/41 women within 1 month post-partum. Ultrasound measurements started at day 10 and were repeated regularly in 40 women. Ultrasound evidence of ovulation was found in 25/40 women. Ultrasound findings appeared not to correspond with the hormonal measurements. It is concluded that the resumption of pituitary and ovarian secretory functions post-partum is not always paralleled by a concomitant recovery of normal follicular growth and ovulation. Application of a progesterone threshold to judge resumption of ovulation post-partum should be reconsidered.

引用

页码：746 / 750

页数：5

共 15 条

[1]

Bryce R.L., Shuter B., Sinosich M.J., Stiel J.N., Picker R.H., Saunders D.M., The value of ultrasound, gonadotropin, and estradiol measurements for precise ovulation prediction, Fertil. Steril, 37, pp. 42-45, (1982)

[2]

Calvo F.O., Keutmann H.T., Bergert E.R., Ryan R.J., Deglycosylated human follitropin: Characterization and effects on adenosine, 3', 5'-phosphate production in porcine granulosa cells, Biochemistry, 25, pp. 3938-3943, (1986)

[3]

Donnet M.L., Howie P.W., Mamie M., Cooper W., Lewis M., Return of ovarian function following spontaneous abortion, Clin. Endocrinol, 33, pp. 13-20, (1990)

[4]

Gray R.H., Campbell O.M., Zacur H.A., Labbok M.H., Macrae S.L., Post partum return of ovarian activity in nonbreastfeeding women monitored by urinary assays, J. Clin. Endocrinol. Metab, 64, pp. 645-650, (1987)

[5]

Hackeloer B.J., Fleming R., Robinson H.P., Adam A.H., Coutts J., Correlation of ultrasonic and endocrinologic assessment of human follicular development. Am, J. Obstet. Gynecol, 135, pp. 122-126, (1979)

[6]

Hamilton C., The Role of Ultrasound in the Fertility Clinic, (1986)

[7]

Israel R., Mishell D.R., Stone C., Thorneycroft I.H., Moyer D.L., Single luteal phase serum progesterone assay as an indicator of ovulation. Am, J. Obstet. Gynecol, 122, pp. 1043-1046, (1972)

[8]

Jia X.C., Kessel B., Yen S., Tucker E.M., Hsueh A., Serum bioactive follicle-stimulating hormone during the human menstrua] cycle and in hyper- and hypogonadotropic states

[9]

application of a sensitive granulosa cell aromatase bioassay, J. Clin. Endocrinol. Metab, 62, pp. 1243-1249, (1986)

[10]

Kroner J., Rouand R., Vander Heijden P., Scheuekens L.A., Vosmar M., Langranjan J., Lactation inhibition by a single injection of a new depot bromocriptine, Br, J. Obstet. Gynaecol, 97, pp. 527-532, (1990)

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