HISTAMINE MODULATES THE INTERLEUKIN-6-REGULATED ACUTE PHASE PROTEIN-SYNTHESIS IN CULTURED MURINE HEPATOCYTES

被引：10

作者：

ROKITA, H

FALUS, A

BIRO, J

SMOLEN, J

KORDULA, T

STALINSKA, K

机构：

[1] NATL INST RHEUMATISM & PHYSIOTHERAPY,DEPT MOLEC BIOL,POB 54,H-1525 BUDAPEST 114,HUNGARY

[2] JAGIELLONIAN UNIV,INST MOLEC BIOL,PL-31007 KRAKOW,POLAND

[3] BOLTZMANN INST,DEPT MED 2,VIENNA,AUSTRIA

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1992年 / 35卷 / 06期

关键词：

D O I：

10.1111/j.1365-3083.1992.tb02975.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Murine hepatocytes cultured in the presence of human recombinant interleukin-6 (IL-6) show increased synthesis of fibrinogen and complement component C3 by the addition of histamine. No similar effect was achieved when murine hepatocytes were treated with histamine alone or with histamine and interleukin-1 alpha together. Using histamine-1 (H-1) and H2 receptor antagonists a prevalence of histamine H1 receptor in the enhancement of IL-6-induced effect is suggested.

引用

页码：681 / 685

页数：5

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