PHARMACOLOGICAL STUDIES ON CUTANEOUS INFLAMMATION-INDUCED BY ULTRAVIOLET-IRRADIATION .1. QUANTIFICATION OF ERYTHEMA BY REFLECTANCE COLORIMETRY AND CORRELATION WITH CUTANEOUS BLOOD-FLOW

被引:30
作者
NOSE, T
TSURUMI, K
机构
[1] Department of Pharmacology, Gifu University School of Medicine, Gifu 500
关键词
ULTRAVIOLET ERYTHEMA; ANTIINFLAMMATORY DRUG; INFLAMMATION (CUTANEOUS); SKIN COLORIMETRY; BLOOD FLOW CHANGE;
D O I
10.1254/jjp.62.245
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This study was conducted to quantify the intensity of ultraviolet (UV) erythema in guinea pigs, a method for evaluating anti-inflammatory drugs, and to clarify any correlation of erythema with cutaneous blood flow. Skin color and cutaneous blood flow in non-administered and indomethacin-administered animals were measured by a colorimeter and a laser Doppler flowmeter over time after UV-irradiation treatment. Skin color was indicated by a XYZ colorimetric system and L*a*b* color space. In either colorimetric system, the values of two indices, x and y or a* and b*, increased along with the intensification of erythema. The increase in the chroma (C*) value calculated from a* and b* was UV-dose-dependent. This value was significantly suppressed by indomethacin 0.5 - 4 hr after irradiation, and it was found to be a clear and sensitive index for evaluating the suppressive effect of drugs. Cutaneous blood flow also increased with UV irradiation. Indomethacin significantly suppressed this increase 2 - 3 hr after UV irradiation. The changes of cutaneous blood flow correlated with those of C*. These results suggested C* was a suitable parameter to quantify UV erythema, and the change of skin color in UV erythema reflected the change of cutaneous blood flow.
引用
收藏
页码:245 / 256
页数:12
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