SERUM ELIMINATION HALF-LIFE OF TAMOXIFEN AND ITS METABOLITES IN PATIENTS WITH ADVANCED BREAST-CANCER

被引：15

作者：

DEVOS, D

SLEE, PHTJ

STEVENSON, D

BRIGGS, RJ

机构：

[1] ST ANTONIUS HOSP, NIEUWEGEIN, NETHERLANDS

[2] UNIV SURREY, ROBENS INST, GUILDFORD GU2 5XH, SURREY, ENGLAND

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1992年 / 31卷 / 01期

关键词：

TAMOXIFEN; ADVANCED BREAST CANCER;

D O I：

10.1007/BF00695998

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In breast cancer patients discontinuing chronic tamoxifen therapy, the serum elimination of metabolites X, Y and E paralleled that of tamoxifen, whereas that of metabolite Z did not. The serum elimination of tamoxifen and metabolites X and B was increased by amino-glutethimide treatment, whereas that of metabolites Z, Y, and E was not.

引用

页码：76 / 78

页数：3

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