FATAL OVERDOSE WITH SUSTAINED-RELEASE VERAPAMIL

被引：14

作者：

MACDONALD, D ^{[1
]}

ALGUIRE, PC ^{[1
]}

机构：

[1] MICHIGAN STATE UNIV,CTR CLIN B301,DEPT INTERNAL MED,E LANSING,MI 48864

来源：

AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 1992年 / 303卷 / 02期

关键词：

VERAPAMIL; TOXICITY; CALCIUM CHANNEL BLOCKERS; THERAPY;

D O I：

10.1097/00000441-199202000-00011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Verapamil is generally a safe and effective drug in the treatment of many vascular disorders. During the past 10 years, a number of serious poisonings have been attributed to verapamil overdose. A relatively new problem is toxicity with the sustained-release form of verapamil. Complications of verapamil overdose can be understood as simply an extension of its pharmacologic activity. Consistently effective therapy remains elusive. Specific calcium channel blocker antidotes are under investigation, but supportive therapy remains the mainstay for serious verapamil overdose.

引用

页码：115 / 117

页数：3

共 27 条

[1] EFFECTIVE TREATMENT OF VERAPAMIL INTOXICATION WITH 4-AMINOPYRIDINE IN THE CAT [J].

AGOSTON, S ;

MAESTRONE, E ;

VANHEZIK, EJ ;

KET, JM ;

HOUWERTJES, MC ;

UGES, DRA .

JOURNAL OF CLINICAL INVESTIGATION, 1984, 73 (05) :1291-1296

[2]

BRAUNWALD E, 1982, NEW ENGL J MED, V307, P1618

[3] ACUTE INTOXICATION WITH VERAPAMIL [J].

CANDELL, J ;

VALLE, V ;

SOLER, M ;

RIUS, J .

CHEST, 1979, 75 (02) :200-201

[4] VERAPAMIL TISSUE CONCENTRATIONS IN FATAL CASES [J].

CHAN, LFT ;

CHHUY, LH ;

CROWLEY, RJ .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1987, 11 (04) :171-174

[5]

CRUMP BJ, 1982, LANCET, V2, P939

[6] SIMULTANEOUS DETERMINATION OF THE INTRAVENOUS AND ORAL PHARMACOKINETIC PARAMETERS OF D,L-VERAPAMIL USING STABLE ISOTOPE-LABELED VERAPAMIL [J].

EICHELBAUM, M ;

SOMOGYI, A ;

VONUNRUH, GE ;

DENGLER, HJ .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1981, 19 (02) :133-137

[7] PROFOUND HYPERGLYCEMIA AND METABOLIC-ACIDOSIS AFTER VERAPAMIL OVERDOSE [J].

ENYEART, JJ ;

PRICE, WA ;

HOFFMAN, DA ;

WOODS, L .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1983, 2 (06) :1228-1231

[8]

FOLLATH F, 1986, BR J CLIN PHARMACOKI, V21, P1495

[9] TREATMENT OF SEVERE VERAPAMIL POISONING WITH COMBINED AMRINONE-ISOPROTERENOL THERAPY [J].

GOENEN, M ;

COL, J ;

COMPERE, A ;

BONTE, J .

AMERICAN JOURNAL OF CARDIOLOGY, 1986, 58 (11) :1142-1143

[10]

HATTORI VT, 1982, NEW ENGL J MED, V306, P238

← 1 2 3 →