A SIMPLE TOTAL SYNTHESIS OF NATURALLY-OCCURRING HYDROXY-AMINO ACIDS BY ENZYMATIC KINETIC RESOLUTION

被引：38

作者：

LU, Y ^{[1
]}

MIET, C ^{[1
]}

KUNESCH, N ^{[1
]}

POISSON, JE ^{[1
]}

机构：

[1] CTR ETUD PHARMACEUT,CHIM SUBST THERAPEUT NAT LAB,F-92296 CHATENAY MALABRY,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(00)80128-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Both optically pure enantiomers of GABOB and isoserine were obtained by enzymatic kinetic resolution of acetylated precursors in three or four steps. The key intermediates were cyanohydrins available from simple aldehydes. This procedure can be applied to other unusual hydroxy amino acids widely distributed in biologically important peptides.

引用

页码：893 / 902

页数：10

共 92 条

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