ATP-SENSITIVE K+ CHANNELS IN HEART-MUSCLE CELLS FIRST OPEN AND SUBSEQUENTLY CLOSE AT MAINTAINED ANOXIA

被引：23

作者：

THIERFELDER, S ^{[1
]}

DOEPNER, B ^{[1
]}

GEBHARDT, C ^{[1
]}

HIRCHE, H ^{[1
]}

BENNDORF, K ^{[1
]}

机构：

[1] UNIV COLOGNE,ZENTRUM PHYSIOL & PATHOPHYSIOL,D-50931 COLOGNE,GERMANY

来源：

FEBS LETTERS | 1994年 / 351卷 / 03期

关键词：

PATCH CLAMP; HEART CELL; K-ATP CHANNEL; ANOXIA;

D O I：

10.1016/0014-5793(94)00886-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In ventricular myocardial cells of the guinea pig and the mouse, anoxia caused after a mean latency of 439 +/- 141 s and 129 +/- 23 s (mean +/- S.E.M.), respectively, a large current through K-ATP-channels. This current disappeared within several seconds when reoxygenating the cells but decayed also completely at maintained anoxia. The kinetics of the latter process, however, were much slower and obeyed an approximately monoexponential time course with time constants in the range of 30 s. The results suggest that in the ischaemic myocardium K-ATP-channels contribute only to the initial phase of extracellular K+ accumulation.

引用

页码：365 / 369

页数：5

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