INDUCTION OF MALFORMATIONS BY X-RAY-EXPOSURE OF VARIOUS STAGES OF THE OOGENESIS OF MICE

被引：11

作者：

MULLER, WU

SCHOTTEN, H

机构：

[1] Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, D45122 Essen

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1995年 / 331卷 / 01期

关键词：

OOGENESIS; MALFORMATION; GASTROSCHISIS; RADIATION EXPOSURE;

D O I：

10.1016/0027-5107(95)00057-P

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We studied the effects of ionizing radiation (X-rays, 0-3 Gy, dose rate 1 Gy/min) on various stages of oogenesis of a mouse strain (HLG/Zte) that had been shown previously to respond with an increased number of malformations after radiation exposure of preimplantation stages. Like the results obtained with preimplantation stages, we observed a statistically significant increase in the number of malformed fetuses (exclusively gastroschises) on day 19 of gestation, when oocytes within 1-4 weeks before ovulation were exposed to 2 or 3 Gy. Less mature oocytes were killed by radiation doses of 0.5 Gy and higher. In addition to the increased frequency of malformations, we found a dose-dependent increase of lethal effects (affecting either oocytes or specific gestational stages) and of runts ('dwarfs').

引用

页码：119 / 125

页数：7

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