BIOSYNTHETIC ORIGIN OF THE OXYGEN-ATOMS OF TETRACENOMYCIN-C

被引：14

作者：

UDVARNOKI, G ^{[1
]}

WAGNER, C ^{[1
]}

MACHINEK, R ^{[1
]}

ROHR, J ^{[1
]}

机构：

[1] UNIV GOTTINGEN,INST ORGAN CHEM,D-37077 GOTTINGEN,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 05期

关键词：

BIOSYNTHESIS; NATURAL PRODUCTS; TETRACENOMYCIN C;

D O I：

10.1002/anie.199505651

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Water and not acetate is the source of the oxygen atom 4a‐OH in the biosynthesis of tetracenomycin C. Based on this unusual finding, an intermediate epoxide is postulated, which has to be “cis opened” to attain the required stereochemistry at C‐4a and C‐12a (see reaction sequence below). (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：565 / 567

页数：3

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