ROLE OF PHOSPHOLIPID IN ADRENALINE-INDUCED LIPOLYSIS AND CYCLIC-AMP PRODUCTION

被引：10

作者：

OKUDA, H ^{[1
]}

SAITO, Y ^{[1
]}

MATSUOKA, N ^{[1
]}

TAKEDA, E ^{[1
]}

KUMAGAI, A ^{[1
]}

机构：

[1] CHIBA UNIV,SCH MED,DEPT INTERNAL MED 2,CHIBA 280,JAPAN

来源：

JOURNAL OF BIOCHEMISTRY | 1978年 / 83卷 / 03期

关键词：

D O I：

10.1093/oxfordjournals.jbchem.a131986

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid micelles consisting of a glyceride mixture (triolein, diolein, and monoolein) and lecithin bound adrenaline-14C more strongly than did micelles consisting of the glyceride mixture only. Lipid micelles consisting of the glyceride mixture and phosphatidic acid also bound adrenaline-14C effectivily, whereas lipid micelles consisting of the glyceride mixture and diglyceride, obtained from lecithin, did not bind the hormone strongly. Both phenoxybenzamine (an αblocker) and propranolol (a β-blocker) strongly inhibited the association between adrenaline-14C and lipid micelles consisting of the glyceride mixture and lecithin. Propranolol, inhibited adrenaline-induced lipolysis in both fat cells and fat globules, whereas, phenoxybenzamine, did not affect adrenaline-induced lipolysis. Both agents reduced adrenaline-induced adenylcyclase activation in fat cell ghosts. Phospholipid was also found to be related with adrenaline-mediated adenylcyclase activation. © 1978 BY THE JOURNAL OF BIOCHEMISTRY.

引用

页码：887 / 892

页数：6

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