A ROLE FOR ELEVATED PLASMA-CORTICOSTERONE IN MODULATION OF HOST RESPONSE DURING INFECTION WITH TRICHINELLA-PSEUDOSPIRALIS

被引：39

作者：

STEWART, GL ^{[1
]}

MANN, MA ^{[1
]}

UBELAKER, JE ^{[1
]}

MCCARTHY, JL ^{[1
]}

WOOD, BG ^{[1
]}

机构：

[1] SO METHODIST UNIV, DEPT BIOL, DALLAS, TX 75275 USA

来源：

PARASITE IMMUNOLOGY | 1988年 / 10卷 / 02期

关键词：

D O I：

10.1111/j.1365-3024.1988.tb00210.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Suppression of host inflammatory response in mice infected with Trichinella pseudospiralis was associated with host plasma corticosterone levels significantly higher than those seen in uninfected mice or in mice infected with T. spiralis. Increases in the population of mitochondria and depletion of lipid droplets in cells of the zona fasciculata were seen in the adrenals of mice infected with T. pseudospiralis. Elevations in enteritis, myositis and myocarditis accompanied 100% mortality in adrenalectomized mice infected with T. pseudospiralis, while lower levels of inflammation and no morality were observed in sham operated or intact animals infected with this parasite. The severe myositis normally accompanying infection with T. spiralis was suppressed by concurrent infection with 1000 or 2000 T. pseudospiralis to levels equivalent to those seen in animals receiving 0.15 and 0.41 mg cortisone acetate/25 g mouse/day, respectively.

引用

页码：139 / 150

页数：12

共 35 条

[1]

ALKARMI TO, 1981, J PARASITOL, V67, P685, DOI 10.2307/3280442

[2] A COMPARISON OF THE SURFACE AND SECRETIONS OF TRICHINELLA-PSEUDOSPIRALIS AND TRICHINELLA-SPIRALIS [J].