NON-STEROIDAL ANTI-INFLAMMATORY DRUGS - EFFECT ON PYLORIC SPHINCTER AND DUODENOGASTRIC REFLUX

被引：12

作者：

PANTOJA, JL ^{[1
]}

DEFILIPPI, C ^{[1
]}

VALENZUELA, JE ^{[1
]}

CSENDES, A ^{[1
]}

机构：

[1] UNIV CHILE,SCH MED,DEPT PHYSIOL,SANTIAGO,CHILE

来源：

DIGESTIVE DISEASES AND SCIENCES | 1979年 / 24卷 / 03期

关键词：

D O I：

10.1007/BF01308433

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We have investigated the effect of nonsteroidal antiinflammatory drugs on canine pyloric sphincter pressure, mucosal potential difference (PD), and duodenogastric reflux in 5 dogs. Only intragastric aspirin at doses of 30 and 100 mg/kg caused a significant (P<0.05) decrease in pyloric sphincter pressure, an increase of duodenogastric reflux, and changed the mucosal PD. Neither intravenous aspirin, intragastric phenylbutazone, or intrarectal indomethacin produced these changes. The mechanism for the aspirin effect may be mediated by local pathways related to changes in mucosal PD. We postulate that increased duodenogastric reflux may be an aggravating factor for the gastric mucosal damage caused by intragastric aspirin. © 1979 Digestive Disease Systems, Inc.

引用

页码：217 / 220

页数：4

共 14 条

[1]

BUGAT R, 1976, GASTROENTEROLOGY, V71, P754

[2] RESPONSE OF HUMAN CARDIAC SPHINCTER TO CIRCULATING PROSTAGLANDINS-F2ALPHA AND E2 AND TO ANTIINFLAMMATORY DRUGS [J].