CHARACTERIZATION OF A POLYMORPHIC IMMUNODOMINANT MOLECULE IN SPOROZOITES AND SCHIZONTS OF THEILERIA-PARVA

被引：58

作者：

TOYE, PG

GODDEERIS, BM

IAMS, K

MUSOKE, AJ

MORRISON, WI

机构：

[1] International Laboratory for Research on Animal Diseases, Nairobi

来源：

PARASITE IMMUNOLOGY | 1991年 / 13卷 / 01期

关键词：

THEILERIA-PARVAFIMMUNODOMINANT ANTIGEN;

D O I：

10.1111/j.1365-3024.1991.tb00262.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study examines several aspects of a polymorphic, immunodominant molecule (PIM) found in the protozoan parasite, Theileria parva. The antigen is present in all T.p. parva stocks examined, and in the related subspecies, T.p. bovis and T.p. lawrencei. It is the predominant antigen recognized by antisera from immune cattle on Western blot analysis of schizont-infected lymphocytes, and is the only antigen which has been shown to react with anti-schizont monoclonal antibodies (MoAbs) on Western blots or in immunoprecipitations The antigen shows polymorphism in both size and expression of antibody epitopes among the different stocks of T. parva. The antigen is present in sporozoites as well as schizonts.

引用

页码：49 / 62

页数：14

共 16 条

[1] INFECTION AND TRANSFORMATION OF BOVINE LYMPHOID-CELLS IN-VITRO BY INFECTIVE PARTICLES OF THEILERIA-PARVA [J].