MANIPULATION OF CELL-CYCLE KINETICS - INFLUENCE ON THE CYTOTOXICITY OF DOXORUBICIN IN HUMAN BREAST-CANCER CELLS

被引：10

作者：

BONTENBAL, M ^{[1
]}

SIEUWERTS, AM ^{[1
]}

PETERS, HA ^{[1
]}

SONNEVELD, P ^{[1
]}

FOEKENS, JA ^{[1
]}

KLIJN, JGM ^{[1
]}

机构：

[1] ERASMUS UNIV,HOSP DIJKZIGT,DEPT HEMATOL,3015 GD ROTTERDAM,NETHERLANDS

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1990年 / 37卷 / 06期

关键词：

D O I：

10.1016/0960-0760(90)90472-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In vitro exposure of estrogen receptor-negative (ER-) EVSA-T human breast cancer cells to insulin and/or estradiol had no effect on cell cycle distribution, in contrast to a 3-5-fold increase in the percentages of cells in the S-phase of the cell cycle in the ER+ MCF-7 cell line. Estrogen pretreatment of MCF-7 cells followed by incubation with doxorubicin resulted in an augmented inhibition of cell growth compared to unstimulated controls. This delay in growth was accompanied by a decrease in the percentages of cells actively synthesizing DNA, and by an augmented percentage of cells exhibiting a G2M-amount of DNA at the end of a 6-9 day period of culture in complete growth medium.

引用

页码：1097 / 1101

页数：5

共 17 条

[1]

ALLEGRA JC, 1983, SEMIN ONCOL, V10, P23

[2] EFFECT OF HORMONAL MANIPULATION AND DOXORUBICIN ADMINISTRATION ON CELL-CYCLE KINETICS OF HUMAN-BREAST CANCER-CELLS [J].

BONTENBAL, M ;

SIEUWERTS, AM ;

KLIJN, JGM ;

PETERS, HA ;

KRIJNEN, HLJM ;

SONNEVELD, P ;

FOEKENS, JA .

BRITISH JOURNAL OF CANCER, 1989, 60 (05) :688-692

[3] ESTRADIOL ENHANCES DOXORUBICIN UPTAKE AND CYTO-TOXICITY IN HUMAN-BREAST CANCER-CELLS (MCF-7) [J].

BONTENBAL, M ;

SONNEVELD, P ;

FOEKENS, JA ;

KLIJN, JGM .

EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1988, 24 (09) :1409-1414

[4] ESTROGEN-RECEPTOR STATUS AND THE RESPONSE OF HUMAN-BREAST CANCER CELL-LINES TO A COMBINATION OF METHOTREXATE AND 17-BETA ESTRADIOL [J].

CLARKE, R ;

VANDENBERG, HW ;

KENNEDY, DG ;

MURPHY, RF .

BRITISH JOURNAL OF CANCER, 1985, 51 (03) :365-369

[5] CONVENTIONAL VERSUS CYTOKINETIC POLYCHEMOTHERAPY WITH ESTROGENIC RECRUITMENT IN METASTATIC BREAST-CANCER - RESULTS OF A RANDOMIZED COOPERATIVE TRIAL [J].

CONTE, PF ;

PRONZATO, P ;

RUBAGOTTI, A ;

ALAMA, A ;

AMADORI, D ;

DEMICHELI, R ;

GARDIN, G ;

GENTILINI, P ;

JACOMUZZI, A ;

LIONETTO, R ;

MONZEGLIO, C ;

NICOLIN, A ;

ROSSO, R ;

SISMONDI, P ;

SUSSIO, M ;

SANTI, L .

JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (03) :339-347

[6] ESTROGEN POTENTIATES TOPOISOMERASE-II-MEDIATED CYTO-TOXICITY IN AN ACTIVATED SUBPOPULATION OF HUMAN-BREAST CANCER-CELLS - IMPLICATIONS FOR CYTO-TOXIC DRUG-RESISTANCE IN SOLID TUMORS [J].

EPSTEIN, RJ ;

SMITH, PJ ;

WATSON, JV ;

WATERS, C ;

BLEEHEN, NM .

INTERNATIONAL JOURNAL OF CANCER, 1989, 44 (03) :501-505

[7] CHARACTERIZATION OF VP-16-INDUCED DNA CLEAVAGE IN ESTROGEN-STIMULATED HUMAN-BREAST CANCER-CELLS [J].

EPSTEIN, RJ ;

SMITH, PJ ;

WATSON, JV ;

BLEEHEN, NM .

BRITISH JOURNAL OF CANCER, 1988, 57 (05) :445-450

[8]

EPSTEIN RJ, 1988, CANCER RES, V48, P297

[9] ADJUVANT CHEMOTHERAPY WITH AND WITHOUT TAMOXIFEN IN THE TREATMENT OF PRIMARY BREAST-CANCER - 5-YEAR RESULTS FROM THE NATIONAL SURGICAL ADJUVANT BREAST AND BOWEL PROJECT TRIAL [J].

FISHER, B ;

REDMOND, C ;

BROWN, A ;

FISHER, ER ;

WOLMARK, N ;

BOWMAN, D ;

PLOTKIN, D ;

WOLTER, J ;

BORNSTEIN, R ;

LEGAULTPOISSON, S ;

SAFFER, EA .

JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (04) :459-471

[10]

HUG V, 1986, CANCER RES, V46, P147

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