TRANSGLUTAMINASE LEVELS IN DUPUYTRENS DISEASE

被引：8

作者：

DOLYNCHUK, KN

PETTIGREW, NM

机构：

[1] Departments of Surgery, Biochemistry and Molecular Biology, and Pathology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba

来源：

JOURNAL OF HAND SURGERY-AMERICAN VOLUME | 1991年 / 16A卷 / 05期

关键词：

D O I：

10.1016/S0363-5023(10)80136-4

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

By use of immunoperoxidase staining, tissue transglutaminase and aminopropeptide of collagen type III were localized to fibroblasts running within cords of Dupuytren's fascia. Quantitative analysis of transglutaminase revealed that activity levels were significantly higher in acutely contracting fascia than in chronic contractures. The results show that contractures in Dupuytren's fascia may be reflected by the level of transglutaminase activity in the tissue. Furthermore, it is suggested that isopeptide bond formation, involving collagen type III aminopropeptide moieties, may be the biochemical mechanism by which transglutaminase maintains the contracted state.

引用

页码：787 / 790

页数：4

共 13 条

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