BRAIN BETA-ADRENOCEPTOR BINDING-SITES IN DEPRESSED SUICIDE VICTIMS - EFFECTS OF ANTIDEPRESSANT TREATMENT

Beta-Adrenoceptor binding sites were measured by saturation binding of [H-3]CGP 12177 in nine brain regions from 13 suicides, with a firm retrospective diagnosis of depression, who had been receiving antidepressant drugs, and 11 matched controls. Significantly lower numbers of beta-adrenoceptor binding sites were found in thalamus and temporal cortex (Brodmann area 38), but not in other brain regions, of antidepressant-treated suicides compared to controls. The lower number of beta-adrenoceptor binding sites in thalamus appeared to be related to drug treatment, whereas lower numbers of beta-adrenoceptors in temporal cortex were also found in antidepressant-free suicides.