A QUARTZ CRYSTAL VISCOSITY SENSOR FOR MONITORING COAGULATION REACTION AND ITS APPLICATION TO A MULTICHANNEL COAGULATION DETECTOR

被引:42
作者
MURAMATSU, H
KIMURA, K
ATAKA, T
HOMMA, R
MIURA, Y
KARUBE, I
机构
[1] NATL INST HLTH, DEPT BLOOD PROD, SHINAGAWA KU, TOKYO 141, JAPAN
[2] UNIV TOKYO, ADV SCI & TECHNOL RES CTR, MEGURO KU, TOKYO 153, JAPAN
关键词
QUARTZ CRYSTAL; VISCOSITY SENSOR; BLOOD COAGULATION FACTORS;
D O I
10.1016/0956-5663(91)85022-O
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
A quartz crystal viscosity sensor was applied to a coagulation reaction monitoring system. The system consists of 16 oscillating circuits, a channel selector, a frequency counter, a temperature controller and a microcomputer. The system is named the Quartz Chemical Analyzer (QCA). AT-cut quartz crystals (9 MHz) were used as viscosity detectors and were attached to a cell in order to expose only one side of the quartz plate. The system was applied to the detection of the blood coagulation factors VIII (F VIII) and IX (F IX). The activity of these factors was assayed by a single-stage method. A linear relationship was obtained in a double-logarithmic diagram of concentration versus coagulation time with respect to F VIII and F IX in the range 0.05-0.4 unit cm-3 and 0.025-0.2 unit cm-3, respectively.
引用
收藏
页码:353 / 358
页数:6
相关论文
共 17 条
  • [1] BASIC MECHANISMS IN BLOOD-COAGULATION
    DAVIE, EW
    FUJIKAWA, K
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1975, 44 : 729 - 829
  • [2] HARDISTY RM, 1962, THROMB DIATH HAEMOST, V7, P215
  • [3] APPLICATIONS OF PIEZOELECTRIC CRYSTAL DETECTOR IN ANALYTICAL-CHEMISTRY
    HLAVAY, J
    GUILBAULT, GG
    [J]. ANALYTICAL CHEMISTRY, 1977, 49 (13) : 1890 - 1898
  • [4] KANAZAWA KK, 1985, ANAL CHIM ACTA, V175, P99
  • [5] PIEZOELECTRIC SORPTION DETECTOR
    KING, WH
    [J]. ANALYTICAL CHEMISTRY, 1964, 36 (09) : 1735 - &
  • [6] MIURA Y, 1989, THROMB HAEMOSTASIS, V62, P78
  • [7] MIURA Y, 1984, J JPN SOC BLOOD TRAN, V30, P114
  • [8] MURAMATSU H, 1989, ANAL LETT, V22, P2155
  • [9] PIEZOELECTRIC IMMUNO SENSOR FOR THE DETECTION OF CANDIDA-ALBICANS MICROBES
    MURAMATSU, H
    KAJIWARA, K
    TAMIYA, E
    KARUBE, I
    [J]. ANALYTICA CHIMICA ACTA, 1986, 188 : 257 - 261
  • [10] COMPUTATION OF EQUIVALENT-CIRCUIT PARAMETERS OF QUARTZ CRYSTALS IN CONTACT WITH LIQUIDS AND STUDY OF LIQUID PROPERTIES
    MURAMATSU, H
    TAMIYA, E
    KARUBE, I
    [J]. ANALYTICAL CHEMISTRY, 1988, 60 (19) : 2142 - 2146