INDUCED FIT AS A DETERMINATIVE OF IONOPHORE SELECTIVITY

被引：18

作者：

PAINTER, G

PRESSMAN, BC

机构：

[1] Univ. of Miami School of Medicine, Miami

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 03期

关键词：

D O I：

10.1016/0006-291X(79)91996-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The conformation of the carboxylic ionophore salinomycin has been examined in a variety of solvents by circular dichroism. The solution conformation of the ionophore has been correlated with Na+ and K+ affinity and selectivity. Cation selectivity appears to be a function of both the initial conformation of the free anionic ionophore and the ability of the latter to reorient about the cation. An analogy to the induced fit model of enzyme-substrate interaction is proposed. © 1979.

引用

收藏

页码：1117 / 1122

页数：6

相关论文

共 16 条

[1] Volumes and hydration warmth of ions [J].

Born, M .

ZEITSCHRIFT FUR PHYSIK, 1920, 1 :45-48

[2]

DEGANI H, 1974, BIOCHEMISTRY-US, V13, P5022, DOI 10.1021/bi00721a025

[3] KINETICS OF MONENSIN COMPLEXATION WITH SODIUM IONS BY NA-23 NMR-SPECTROSCOPY [J].

DEGANI, H .

BIOPHYSICAL CHEMISTRY, 1977, 6 (03) :345-349

[4]

DJERASSI C, 1960, OPTICAL ROTATORY DIS, P41

[5] EFFECTS OF MACROTETRALIDE ACTIN ANTIBIOTICS ON EQUILIBRIUM EXTRACTION OF ALKALI METAL SALTS INTO ORGANIC SOLVENTS [J].

EISENMAN, G ;

CIANI, S ;

SZABO, G .

JOURNAL OF MEMBRANE BIOLOGY, 1969, 1 (03) :294-&

[6] 2-PHASE PARTITION STUDIES OF ALKALI CATION COMPLEXATION BY IONOPHORES [J].

HAYNES, DH ;

PRESSMAN, BC .

JOURNAL OF MEMBRANE BIOLOGY, 1974, 18 (01) :1-21

[7] COMPARISON OF EXPERIMENTAL BINDING DATA AND THEORETICAL MODELS IN PROTEINS CONTAINING SUBUNITS [J].

KOSHLAND, DE ;

NEMETHY, G ;

FILMER, D .

BIOCHEMISTRY, 1966, 5 (01) :365-+

[8] THE EFFECT OF SOLVENT ON SPECTRA .1. A NEW EMPIRICAL MEASURE OF SOLVENT POLARITY - Z-VALUES [J].

KOSOWER, EM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (13) :3253-3260

[9] STRUCTURE AND OPTICAL ROTATORY DISPERSION OF SATURATED KETONES [J].

MOFFITT, W ;

WOODWARD, RB ;

MOSCOWITZ, A ;

KLYNE, W ;

DJERASSI, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1961, 83 (19) :4013-&

[10] TEMPERATURE DEPENDENCE OF AMIDE PROTON CHEMICAL SHIFTS - SECONDARY STRUCTURES OF GRAMICIDIN S AND VALINOMYCIN [J].

OHNISHI, M ;

URRY, DW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1969, 36 (02) :194-&