THE INTERFERON FAMILY STIMULATES THE SECRETIONS OF PROLACTIN AND INTERLEUKIN-6 BY THE PITUITARY-GLAND INVITRO

被引：38

作者：

YAMAGUCHI, M ^{[1
]}

KOIKE, K ^{[1
]}

MATSUZAKI, N ^{[1
]}

YOSHIMOTO, Y ^{[1
]}

TANIGUCHI, T ^{[1
]}

MIYAKE, A ^{[1
]}

TANIZAWA, O ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT OBSTET & GYNECOL,1-1-50 FUKUSHIMA,FUKUSHIMA KU,OSAKA 553,JAPAN

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 1991年 / 14卷 / 06期

关键词：

INTERFERON-ALPHA; INTERFERON-BETA-1; INTERFERON-GAMMA; INTERLEUKIN-6; PROLACTIN; PITUITARY CELLS;

D O I：

10.1007/BF03346841

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of interferon-alpha, interferon-beta-1 and interferon-gamma on the secretions of prolactin (PRL) and interleukin-6 by primary cultured rat anterior pituitary cells were examined. These three interferons caused dose-dependent increases in PRL secretion within 30 min, and dose-dependent stimulation of interleukin-6 were weaker than the effects of interleukin-1 and tumor necrosis factor-alpha. These results suggest that interferons regulate PRL secretion from the pituitary gland, and that there may be a pathway in which interferons stimulate PRL secretion through interleukin-6 release.

引用

页码：457 / 461

页数：5

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