EXPRESSION OF THE HEPARIN-BINDING GROWTH-FACTOR RECEPTOR GENES IN HUMAN MEGAKARYOCYTIC LEUKEMIA-CELLS

被引：24

作者：

KATOH, O

HATTORI, Y

SATO, T

KIMURA, A

KURAMOTO, A

SUGIMURA, T

TERADA, M

机构：

[1] CHIBA UNIV,SCH MED,DEPT PEDIAT,CHIBA 280,JAPAN

[2] HIROSHIMA UNIV,NUCL MED & BIOL RES INST,DEPT INTERNAL MED,MINAMI KU,HIROSHIMA 734,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 183卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)91612-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

K- sam bek, N- sam flg and FGFR3 sam3 establish gene family of the receptors for heparin-binding growth factors (HBGFs) or FGFs. These mRNAs were detected in human leukemia cells, CMK, K562 and HEL, which have megakaryocytic phenotype or the potency to differentiate into megakaryocytic lineage. In CMK cells N- sam flg transcript level was enhanced by the culture with 12-O-tetradecanoylphorbol-13-acetate (TPA). cDNA-polymerase chain reaction identified K- sam bek mRNA in human platelets, suggesting the involvement of HBGFs in megakaryocytopoiesis and functions of platelets. © 1992.

引用

页码：83 / 92

页数：10

共 28 条

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