CELL-CYCLE PARAMETERS AS BIOLOGICAL PREDICTORS OF PROGNOSIS IN AML - A REVIEW AND UPDATE OF CELL-CYCLE KINETICS AND REMISSION INDUCTION DURATION IN ACUTE-LEUKEMIA

被引：6

作者：

BOKHARI, SAJ ^{[1
]}

ABBAS, A ^{[1
]}

YOUSUF, N ^{[1
]}

MEHDI, A ^{[1
]}

UMERANI, A ^{[1
]}

QADIR, K ^{[1
]}

SHEIKH, Y ^{[1
]}

AKHTAR, S ^{[1
]}

CHUGHTAI, S ^{[1
]}

PREISLER, H ^{[1
]}

RAZA, A ^{[1
]}

机构：

[1] UNIV CINCINNATI,MED CTR,DEPT INTERNAL MED,DIV HEMATOL & ONCOL,CINCINNATI,OH 45267

来源：

LEUKEMIA & LYMPHOMA | 1992年 / 6卷 / 03期

关键词：

ACUTE MYELOID LEUKEMIA; CELL CYCLE; REMISSION INDUCTION; REMISSION DURATION; BROMODEOXYURIDINE; IODODEOXYURIDINE;

D O I：

10.3109/10428199209064896

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although the prognostic and clinical significance of cell cycle kinetic studies in neoplastic diseases has been inconclusive at worst and controversial at best, new advances in techniques to study cell cycle characteristics have dramatically improved our ability to more accurately measure the parameters of labeling index (LI), S-phase time (Ts) and total cell cycle time (Tc), and subsequently to find any correlations which would enable us to use these as prognostic indicators. Data from 285 patients with acute myeloid leukemia (AML) who were given in-vivo infusion of the thymidine analogue bromodeoxyuridine (BrdU) prior to chemotherapy show differences in mean labeling indices derived from bone marrow aspirates versus biopsies-being 9.2% and 22.2% respectively. The Tc and Ts were obtained by double labeling the aspirates with tritiated thymidine in-vitro. In 102 uniformly treated patients with standard risk de novo AML, correlations between cell cycle parameters thus measured and clinical data were sought. Although no relation of cell cycle characteristics to remission induction outcome was observed, patients with below median biopsy LI and above median Tc showed longer remission durations (p = 0.02 and 0.04). We conclude that patients with slowly cycling leukemias have longer and more durable remissions most probably as a result of retarded regrowth of leukemic myeloblasts between courses of consolidation therapy. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：197 / 207

页数：11

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