INHIBITION OF REV ACTIVITY AND HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION BY ANTISENSE OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE ANALOGS DIRECTED AGAINST THE REV-RESPONSIVE ELEMENT

被引：29

作者：

LI, G

LISZIEWICZ, J

SUN, D

ZON, G

DAEFLER, S

WONGSTAAL, F

GALLO, RC

KLOTMAN, ME

机构：

[1] NCI,TUMOR CELL BIOL LAB,BETHESDA,MD 20892

[2] LYNX THERAPEUT INC,FOSTER CITY,CA 94404

[3] NYU MED CTR,DEPT MED,NEW YORK,NY 10016

[4] UNIV CALIF SAN DIEGO,DEPT MED,LA JOLLA,CA 92093

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 11期

关键词：

D O I：

10.1128/JVI.67.11.6882-6888.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. We demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy.

引用

页码：6882 / 6888

页数：7

共 73 条

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