Control of morphogenesis and differentiation by HOM/Hox genes

被引：120

作者：

Botas, Juan ^{[1
]}

机构：

[1] Baylor Coll Med, Inst Mol Genet, Houston, TX 77030 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0955-0674(93)90086-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HOM/Hox genes are master regulatory switches that specify axial identity and control the growth and differentiation of groups of cells related by position. HOM/Hox genes function combinatorially and hierarchically to specify cell fate. Some of the genes they regulate and that mediate specific identity functions have been identified. Research in Drosophila has shown that HOM genes are continuously required during development for correct axial identity.

引用

页码：1015 / 1022

页数：8

共 85 条

[1] THE HUMAN HOX GENE FAMILY [J].

ACAMPORA, D ;

DESPOSITO, M ;

FAIELLA, A ;

PANNESE, M ;

MIGLIACCIO, E ;

MORELLI, F ;

STORNAIUOLO, A ;

NIGRO, V ;

SIMEONE, A ;

BONCINELLI, E .

NUCLEIC ACIDS RESEARCH, 1989, 17 (24) :10385-10402

[2] DNA-BINDING PROPERTIES OF THE PURIFIED ANTENNAPEDIA HOMEODOMAIN [J].

AFFOLTER, M ;

PERCIVALSMITH, A ;

MULLER, M ;

LEUPIN, W ;

GEHRING, WJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (11) :4093-4097

[3]

AKAM M, 1987, DEVELOPMENT, V101, P1

[4] DEFORMED AUTOREGULATORY ELEMENT FROM DROSOPHILA FUNCTIONS IN A CONSERVED MANNER IN TRANSGENIC MICE [J].

AWGULEWITSCH, A ;

JACOBS, D .

NATURE, 1992, 358 (6384) :341-344

[5] CRANIOFACIAL ABNORMALITIES INDUCED BY ECTOPIC EXPRESSION OF THE HOMEOBOX GENE HOX-1.1 IN TRANSGENIC MICE [J].

BALLING, R ;

MUTTER, G ;

GRUSS, P ;

KESSEL, M .

CELL, 1989, 58 (02) :337-347

[6] STRUCTURE AND FUNCTION OF THE HOMEOTIC GENE-COMPLEX (HOM-C) IN THE BEETLE, TRIBOLIUM-CASTANEUM [J].

BEEMAN, RW ;

STUART, JJ ;

BROWN, SJ ;

DENELL, RE .

BIOESSAYS, 1993, 15 (07) :439-444

[7] DIFFERENTIATION REQUIRES CONTINUOUS ACTIVE CONTROL [J].

BLAU, HM .

ANNUAL REVIEW OF BIOCHEMISTRY, 1992, 61 :1213-1230

[8]

BROOKMAN JJ, 1992, DEVELOPMENT, V116, P1185

[9] THE LOCALIZATION AND REGULATION OF ANTENNAPEDIA PROTEIN EXPRESSION IN DROSOPHILA EMBRYOS [J].

CARROLL, SB ;

LAYMON, RA ;

MCCUTCHEON, MA ;

RILEY, PD ;

SCOTT, MP .

CELL, 1986, 47 (01) :113-122

[10] DETERMINATION OF BLASTODERM CELLS IN DROSOPHILA-MELANOGASTER [J].

CHAN, LN ;

GEHRING, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (09) :2217-&

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