POLYMORPHISM OF THE 35-KILODALTON AND 50-KILODALTON SURFACE GLYCOCONJUGATES OF TRYPANOSOMA-CRUZI METACYCLIC TRYPOMASTIGOTES

被引：63

作者：

MORTARA, RA

DASILVA, S

ARAGUTH, MF

BLANCO, SA

YOSHIDA, N

机构：

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 11期

关键词：

D O I：

10.1128/IAI.60.11.4673-4678.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we examined the immunochemical properties of the 35- and 50-kDa (35/50-kDa) surface glycoconjugates expressed on the surface of metacyclic trypomastigotes of Trypanosoma cruzi using three different monoclonal antibodies directed to this component. The 35/50-kDa surface antigen was expressed by metacyclic trypomastigotes of 11 different strains of T. cruzi and displayed a significant degree of molecular polymorphism. Results of immunoblotting and complement-mediated lysis were consistent with such diversity. Different monoclonal antibodies reacted with distinct epitopes on the 35/50-kDa antigen, which is resistant to proteases and behaves as an amphiphilic component.

引用

页码：4673 / 4678

页数：6

共 31 条

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