THE ANTINOCICEPTIVE EFFECT OF NONNOXIOUS SENSORY STIMULATION IS MEDIATED PARTLY THROUGH OXYTOCINERGIC MECHANISMS

被引:138
作者
UVNASMOBERG, K [1 ]
BRUZELIUS, G [1 ]
ALSTER, P [1 ]
LUNDEBERG, T [1 ]
机构
[1] KAROLINSKA INST,DEPT PHYSIOL,S-10401 STOCKHOLM 60,SWEDEN
来源
ACTA PHYSIOLOGICA SCANDINAVICA | 1993年 / 149卷 / 02期
关键词
ANALGESIC EFFECTS; NONNOXIOUS SOMATOSENSORY STIMULATION; OXYTOCIN; OXYTOCIN ANTAGONIST;
D O I
10.1111/j.1748-1716.1993.tb09612.x
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The objective of the present study was to investigate whether oxytocinergic mechanisms may contribute to the antinociceptive effect of non-noxious, sensory stimulation. To test this hypothesis, oxytocin levels in plasma and cerebrospinal fluid (CSF) were measured in control rats as well as in rats exposed for 30 min to electro-acupuncture (2 Hz), thermal stimulation (40-degrees-C) or vibration (100 Hz). All modes of stimulation induced significant elevations of oxytocin levels in plasma and/or in CSF, 30 or 90 min after the end of stimulation. Secondly, the antinociceptive effects of these treatments were investigated in the tail-flick test with and without prior administration of the oxytocin antagonist 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-oxytocin (1 mg kg-1 i.p.). All three modes of stimulation caused a significant delay of the tail-flick latency to the same degree as that caused by injection of oxytocin 1 mg kg-1 i.p. (electro-acupuncture P < 0.01, thermal stimulation and vibration P < 0.05). In all cases, the delay was reversed by administration of the oxytocin antagonist (1 mg kg-1 i.p.). These findings suggest that analgesic effects induced by non-noxious sensory stimulation may, in part, be mediated through activation of oxytocinergic mechanisms.
引用
收藏
页码:199 / 204
页数:6
相关论文
共 23 条
[1]   ENDOGENOUS PAIN CONTROL MECHANISMS - REVIEW AND HYPOTHESIS [J].
BASBAUM, AI ;
FIELDS, HL .
ANNALS OF NEUROLOGY, 1978, 4 (05) :451-462
[2]   ANALGESIA INDUCED BY VAGINAL STIMULATION IN RATS IS APPARENTLY INDEPENDENT OF A MORPHINE-SENSITIVE PROCESS [J].
CROWLEY, WR ;
RODRIGUEZSIERRA, JF ;
KOMISARUK, BR .
PSYCHOPHARMACOLOGY, 1977, 54 (03) :223-225
[3]   ATTENUATION OF PREGNANCY-INDUCED ANALGESIA BY HYPOGASTRIC NEURECTOMY IN RATS [J].
GINTZLER, AR ;
PETERS, LC ;
KOMISARUK, BR .
BRAIN RESEARCH, 1983, 277 (01) :186-188
[4]   DIFFERENTIAL CLEARANCE OF NEUROPHYSIN AND NEUROHYPOPHYSEAL PEPTIDES FROM THE CEREBROSPINAL-FLUID IN CONSCIOUS GUINEA-PIGS [J].
JONES, PM ;
ROBINSON, ICAF .
NEUROENDOCRINOLOGY, 1982, 34 (04) :297-302
[5]  
KNIFFKI KD, 1981, CIRC RES S1, V48, P125
[6]   ADRENAL-MEDULLARY ENKEPHALIN-LIKE PEPTIDES MAY MEDIATE OPIOID STRESS ANALGESIA [J].
LEWIS, JW ;
TORDOFF, MG ;
SHERMAN, JE ;
LIEBESKIND, JC .
SCIENCE, 1982, 217 (4559) :557-559
[7]   PLASMA-LEVELS OF GASTRIN, SOMATOSTATIN, AND CHOLECYSTOKININ IMMUNOREACTIVITY DURING PREGNANCY AND LACTATION IN DOGS [J].
LINDEN, A ;
ERIKSSON, M ;
CARLQUIST, M ;
UVNASMOBERG, K .
GASTROENTEROLOGY, 1987, 92 (03) :578-584
[8]   PAIN ALLEVIATION BY VIBRATORY STIMULATION [J].
LUNDEBERG, T ;
NORDEMAR, R ;
OTTOSON, D .
PAIN, 1984, 20 (01) :25-44
[9]   OXYTOCIN MODULATES THE EFFECTS OF GALANIN IN CARRAGEENAN-INDUCED HYPERALGESIA IN RATS [J].
LUNDEBERG, T ;
MEISTER, B ;
BJORKSTRAND, E ;
UVNASMOBERG, K .
BRAIN RESEARCH, 1993, 608 (02) :181-185
[10]  
LUNDEBERG T, 1982, ACTA PHYSL SCAND S, V338