CGMP ACTS WITHIN CEREBELLAR PURKINJE-CELLS TO PRODUCE LONG-TERM DEPRESSION VIA MECHANISMS INVOLVING PKC AND PKG

被引：96

作者：

HARTELL, NA

机构：

[1] Laboratory for Neural Networks, RIKEN, Wako-shi, Saitama

来源：

NEUROREPORT | 1994年 / 5卷 / 07期

关键词：

LONG TERM DEPRESSION; CGMP; CEREBELLUM; PURKINJE CELL; CLIMBING FIBER; PARALLEL FIBER; PROTEIN KINASE C; PROTEIN KINASE G;

D O I：

10.1097/00001756-199403000-00024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

LONG term depression (LTD) of parallel fibre-Purkinje cell responses may result from desensitization of AMFA (alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid) type glutamate receptors, for which a cascade of reactions involving calcium, inositol-1,4,5-trisphosphate, nitric oxide (NO), guanosine-3'5'-monophosphate (cGMP) and protein kinases C and G has been previously proposed. The involvement of cGMP in synaptic LTD was confirmed by direct injection of cGMP and 8-bromo-cGMP (8-Br-cGMF) into the dendrites of Purkinje cells. Fairing injections with parallel fibre stimulation led to a LTD of synaptic transmission which both occluded and was occluded by heterosynaptically induced LTD. Inhibition of either protein kinases C or G prevented induction of both forms of LTD.

引用

页码：833 / 836

页数：4

共 23 条

[1] QUISQUALATE METABOTROPIC RECEPTORS MODULATE NMDA CURRENTS AND FACILITATE INDUCTION OF LONG-TERM POTENTIATION THROUGH PROTEIN-KINASE-C [J].