EFFECTS OF HELICOBACTER-PYLORI ON HISTAMINE AND CARBACHOL-STIMULATED ACID-SECRETION BY HUMAN PARIETAL-CELLS

被引：30

作者：

JABLONOWSKI, H ^{[1
]}

HENGELS, KJ ^{[1
]}

KRAEMER, N ^{[1
]}

GEIS, G ^{[1
]}

OPFERKUCH, W ^{[1
]}

STROHMEYER, G ^{[1
]}

机构：

[1] RUHR UNIV BOCHUM,W-4630 BOCHUM,GERMANY

来源：

GUT | 1994年 / 35卷 / 06期

关键词：

D O I：

10.1136/gut.35.6.755

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Helicobacter pylori (H pylori) infection is associated with hypo, normal, and hypersecretory disorders of the gastric mucosa. Pathophysiological pathways by which H pylori interacts with acid secretion are still. unclear. The effects of H pylori on (C-14) aminopyrine uptake by human parietal cells were examined as an indirect assay for acid secretion, Isolated oxyntic glands were stimulated with submaximal concentrations of histamine or carbachol and incubated with sonicates of different H pylori strains. Omeprazole and sonicates of Campylobacter jejuni served as positive and negative controls, respectively. Two of four H pylori strains reduced hydrochloric acid sequestration within the parietal cells significantly and in a dose dependent manner in up to 80%. Interaction with acid secretion may therefore constitute a factor contributing to a distinct pathogenicity of H pylori strains.

引用

页码：755 / 757

页数：3

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