THE PROTECTIVE EFFECT OF LICORICE COMPONENTS AND THEIR DERIVATIVES AGAINST GASTRIC-ULCER INDUCED BY ASPIRIN IN RATS

被引：16

作者：

DEHPOUR, AR ^{[1
]}

ZOLFAGHARI, ME ^{[1
]}

SAMADIAN, T ^{[1
]}

VAHEDI, Y ^{[1
]}

机构：

[1] DAROU PAKHSH PHARMACEUT RES CTR,TEHRAN,IRAN

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1994年 / 46卷 / 02期

关键词：

D O I：

10.1111/j.2042-7158.1994.tb03760.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have examined the protective effect of liquorice or its derivatives against gastric ulcer induced by aspirin. A granular mixture of aspirin alone and coated with liquorice or its derivatives including the deglycyrrhized form, a high glycyrrhized form, carbenoxolone, and enoxolone were studied. Aspirin coated with liquorice reduced the number and size of ulcers, reducing the ulcer index from 1.5 +/- 0.12 to 0.5 +/- 0.12 and the incidence from 96% to 46%. Coating with derivatives was less effective (ulcer index, 0.70-0.94; incidence 62-76%).

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收藏

页码：148 / 149

页数：2

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