CALMODULIN STIMULATES HUMAN-PLATELET PHOSPHOLIPASE-A2

被引：320

作者：

WONG, PYK

CHEUNG, WY

机构：

[1] UNIV TENNESSEE,CTR HLTH SCI,DEPT BIOCHEM,MEMPHIS,TN 38163

[2] UNIV TENNESSEE,CTR HLTH SCI,DEPT PHARMACOL,MEMPHIS,TN 38163

[3] ST JUDE CHILDRENS RES HOSP,DEPT BIOCHEM,MEMPHIS,TN 38101

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)91259-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calmodulin is a ubiquitous Ca2+-binding protein, mediating the effect of Ca2+ on many enzyme systems and cellular reactions. Phospholipase A2 (phosphatide-2-acyl-hydrolase, EC 3.1.1.4) which governs the level of arachidonic acid in human platelets, requires Ca2+ for maximum activity. Results presented herein suggest that the stimulation of phospholipase A2 by Ca2+ is also mediated through calmodulin. This finding adds to the growing list of enzymes whose activities are regulated by calmodulin. © 1979.

引用

页码：473 / 480

页数：8

共 37 条

[1] CALCIUM-DEPENDENT REGULATOR OF NAD KINASE IN HIGHER-PLANTS
ANDERSON, JM
CORMIER, MJ
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 84 (03) : 595 - 602
[2] BERGSTROM S, 1964, J BIOL CHEM, V239, P4006
[3] SELECTIVE RELEASE OF ARCHIDONIC ACID FROM PHOSPHOLIPIDS OF HUMAN PLATELETS IN RESPONSE TO THROMBIN
BILLS, TK
SMITH, JB
SILVER, MJ
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1977, 60 (01) : 1 - 6
[4] IDENTIFICATION OF A CALCIUM-BINDING PROTEIN AS A CALCIUM-DEPENDENT REGULATOR OF BRAIN ADENYLATE CYCLASE
BROSTROM, CO
HUANG, YC
BRECKENRIDGE, BM
WOLFF, DJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (01) : 64 - 68
[5] CALCIUM-DEPENDENT ADENYLATE-CYCLASE FROM RAT CEREBRAL-CORTEX - ACTIVATION BY GUANINE NUCLEOTIDES
BROSTROM, MA
BROSTROM, CO
WOLFF, DJ
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1978, 191 (01) : 341 - 350
[6] PROTEIN ACTIVATOR OF CYCLIC 3'-5'-NUCLEOTIDE PHOSPHODIESTERASE OF BOVINE OR RAT-BRAIN ALSO ACTIVATES ITS ADENYLATE CYCLASE
CHEUNG, WY
BRADHAM, LS
LYNCH, TJ
LIN, YM
TALLANT, EA
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 66 (03) : 1055 - 1062
[7] CYCLIC 3,5-NUCLEOTIDE PHOSPHODIESTERASE . DEMONSTRATION OF AN ACTIVATOR
CHEUNG, WY
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1970, 38 (03) : 533 - &
[8] CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE - PRONOUNCED STIMULATION BY SNAKE VENOM
CHEUNG, WY
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1967, 29 (04) : 478 - &
[9] CHEUNG WY, 1971, J BIOL CHEM, V246, P2859
[10] IDENTIFICATION OF CA2+-DEPENDENT MODULATOR PROTEIN AS 4TH SUBUNIT OF RABBIT SKELETAL-MUSCLE PHOSPHORYLASE KINASE
COHEN, P
BURCHELL, A
FOULKES, JG
COHEN, PTW
VANAMAN, TC
NAIRN, AC
[J]. FEBS LETTERS, 1978, 92 (02) : 287 - 293

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