MEDIATORY ROLE OF ENDOTHELIUM-DERIVED NITRIC-OXIDE IN RENAL VASODILATORY AND EXCRETORY EFFECTS OF BRADYKININ

被引：104

作者：

LAHERA, V ^{[1
]}

SALOM, MG ^{[1
]}

FIKSENOLSEN, MJ ^{[1
]}

ROMERO, JC ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,DEPT PHYSIOL & BIOPHYS,ROCHESTER,MN 55905

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 03期

关键词：

BRADYKININ; ENDOTHELIUM-DERIVED NITRIC OXIDE; RENAL HEMODYNAMICS; EXCRETORY FUNCTION L-ARGININE; NG-MONOMETHYL-L-ARGININE;

D O I：

10.1093/ajh/4.3.260

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Intrarenal infusions of 5 ng/kg/min bradykinin (BK) in 5 mg/kg intravenous bolus meclofenamate-treated anesthetized dogs significantly increased renal blood flow, diuresis, natriuresis, and kaliuresis. All these effects were abolished by the simultaneous intrarenal infusion of a competitive inhibitor of nitric oxide synthesis, N(G)-monomethyl-L-arginine (LNMMA). Furthermore, the intrarenal infusion of this inhibitor alone also produced a significant decrease in basal renal blood flow. The administration of L-arginine, a precursor of nitric oxide, prevented the inhibitory effect of LNMMA on the renal vasodilatory and excretory response to BK. Glomerular filtration rate and mean arterial pressure did not change throughout the experiment. It is concluded that the renal vasodilatory and excretory responses to intrarenal BK in meclofenamate-treated dogs are largely dependent on endothelium-derived nitric oxide.

引用

页码：260 / 262

页数：3

共 11 条

[1] Furchgott R.F., Role of the endothelium in responses of vascular smooth muscle, Circ Res, 53, pp. 557-573, (1983)
[2] Palmer R., Ferrige A.G., Moncada S., Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor, Nature (London), 327, pp. 524-525, (1987)
[3] Ignarro L.J., Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein, Circ Res, 65, pp. 1-21, (1989)
[4] Palmer R., Ashton D.S., Moncada S., Vascular endothelial cells synthesize nitric oxide from L-arginine, Nature (London), 333, pp. 664-666, (1988)
[5] Rees D.D., Palmer R., Hodson H.F., Moncada S., A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation, Br J Pharmacol, 96, pp. 418-424, (1989)
[6] Aisaka K., Gross S.S., Griffith O.W., Levi R., NG-methylar-ginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: Does nitric oxide regulate blood pressure in vivo?, Bio-Chem Biophys Res Commun, 160, pp. 881-885, (1989)
[7] Rees D.D., Palmer R., Moncada S., Role of endothelium-derived nitric oxide in the regulation of blood pressure, Proc Natl Acad Sci USA, 86, pp. 3375-3378, (1989)
[8] Fadem S.Z., Hemandez-Llamas G., Patak R.V., Et al., Studies on the mechanism of sodium excretion during drug-induced vasodilatation in the dog, J Clin Invest, 69, pp. 604-610, (1982)
[9] Forsterman U., Hertting G., Neufang B., The role of endothelial and non-endothelial prostaglandins in the relaxation of isolated blood vessels of the rabbit induced by acetylcholine and bradykinin, Br J Pharmac, 87, pp. 521-532, (1986)
[10] Biondi M.L., Dousa T.P., Vanhoutte P.M., Romero J.C., Evidences for the existence of endothelium-derived relaxing factor in the renal medulla, Am J Hypertension, 3, pp. 876-878, (1990)

← 1 2 →