RENAL DENERVATION DECREASES BLOOD-PRESSURE IN DOCA-TREATED MINIATURE SWINE WITH ESTABLISHED HYPERTENSION

被引：37

作者：

OHAGAN, KP ^{[1
]}

THOMAS, GD ^{[1
]}

ZAMBRASKI, EJ ^{[1
]}

机构：

[1] RUTGERS STATE UNIV,DEPT BIOL,PHYSIOL SECT,BARTLETT HALL,NEW BRUNSWICK,NJ 08903

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 01期

关键词：

DOCA; Hypertension; Kidney; Miniature swine; Renal nerves; Sodium;

D O I：

10.1093/ajh/3.1.62

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The role of renal sympathetic nerve activity (RSNA) in the maintenance phase of essential hypertension has not yet been clearly defined. Renal function and mean arterial pressure (MAP) were studied in four Yucatan miniature swine (YMS) with established DOCA hypertension prior to and for 3 weeks after surgical renal denervation (RDX). During the first week post-RDX, MAP decreased from 141 ± 6 to 121 ± 3 mm Hg (P <. 05), while sodium balance increased from 0.32 ± 0.05 to 0.95 ± 0.14 mEq/kg/day (P <. 05). By 3 weeks post-RDX, MAP remained below normotensive levels while sodium balance returned to the pre-RDX value. There was no significant change in potassium or water balance after RDX. Thus, in DOCA-YMS the renal nerves are important in the maintenance of hypertension. The reduction in MAP with RDX in the absence of a natriuresis suggests a role for renal afferent nerve activity. © 1990 by the American Journal of Hypertension, Ltd.

引用

页码：62 / 64

页数：3

共 10 条

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