DIMENSIONAL VERSUS NOSOGRAPHIC APPROACH TO ALZHEIMERS-DISEASE - THERAPEUTIC IMPLICATIONS

被引：2

作者：

DEROUESNE, C

JOUVENT, R

机构：

[1] Department of Neurology, Hôpital de la Salpêtriere and lNSERM, Paris

[2] NSERM, Paris

来源：

NEUROEPIDEMIOLOGY | 1990年 / 9卷 / 04期

关键词：

Alzheimer’s disease; Behavioral disturbances; Cognitive deficits; Therapeutic trials;

D O I：

10.1159/000110770

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Negative results in therapeutic trials in Alzheimer’s disease (AD) usually account for the nonefficacy of the presently tested drugs. However, methodological flaws in the design of these studies, related to the commonly used nosographic approach, can also be implicated in the lack of demonstration of beneficial results. With regard to the heterogeneity of clinical manifestations of AD, the interest of the dimensional, transnosographic approach to cognitive deficits and behavioral disturbances in dementia is suggested for these trials. Both approaches can also be combined, according to the presumed biochemical action of the tested drug in the preclinical studies and the aim of the trial. © 1990 S. Karger AG, Basel.

引用

页码：177 / 182

页数：6

共 23 条

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