INCHING TOWARD REALITY - AN IMPROVED LIKELIHOOD MODEL OF SEQUENCE EVOLUTION

被引：218

作者：

THORNE, JL ^{[1
]}

KISHINO, H ^{[1
]}

FELSENSTEIN, J ^{[1
]}

机构：

[1] UNIV WASHINGTON,DEPT GENET SK-50,SEATTLE,WA 98195

来源：

JOURNAL OF MOLECULAR EVOLUTION | 1992年 / 34卷 / 01期

关键词：

ALIGNMENT; MAXIMUM LIKELIHOOD PROCEDURE; DYNAMIC PROGRAMMING; EVOLUTIONARY MODEL; INSERTION-DELETION MODEL;

D O I：

10.1007/BF00163848

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Our previous evolutionary model is generalized to permit approximate treatment of multiple-base insertions and deletions as well as regional heterogeneity of substitution rates. Parameter estimation and alignment procedures that incorporate these generalizations are developed. Simulations are used to assess the accuracy of the parameter estimation procedure and an example of an inferred alignment is included.

引用

页码：3 / 16

页数：14

共 17 条

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