NEW MACROMOLECULAR CARRIERS FOR DRUGS .1. PREPARATION AND CHARACTERIZATION OF POLY(OXYETHYLENE-B-ISOPRENE-B-OXYETHYLENE) BLOCK COPOLYMER AGGREGATES

被引：78

作者：

ROLLAND, A ^{[1
]}

OMULLANE, J ^{[1
]}

GODDARD, P ^{[1
]}

BROOKMAN, L ^{[1
]}

PETRAK, K ^{[1
]}

机构：

[1] CIBA GEIGY PHARMACEUT CORP,ADV DRUG DELIVERY RES CTR,HORSHAM RH12 4AB,W SUSSEX,ENGLAND

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 1992年 / 44卷 / 07期

关键词：

D O I：

10.1002/app.1992.070440709

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This work describes the formation of discrete micelles (congruent-to 0.1-mu-m) from ABA poly(oxyethylene-b-isoprene-b-oxyethylene) block copolymers in water. An efficient labeling of the micelles by polymerization of [C-14]-styrene within the hydrophobic core is also described. These micellar nanoparticles are being considered as promising materials for controlled release and/or site-specific drug delivery systems. In experimental animals the micelles remained in circulation with a half-life in excess of 50 h. Our results demonstrate the advantages of using block copolymers for the preparation of "perfect" biocompatible surfaces such as are required for well-tolerated, long-circulating particulate drug carriers.

引用

页码：1195 / 1203

页数：9

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