THE EFFECT OF AN OIL FORMULATION ON THE SYSTEMIC AVAILABILITY OF OXFENDAZOLE

被引：4

作者：

ALI, DN ^{[1
]}

CHICK, BF ^{[1
]}

机构：

[1] AGRISEARCH SERV PTY LTD,ARMIDALE,NSW 2350,AUSTRALIA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1992年 / 22卷 / 04期

关键词：

OXFENDAZOLE; FENBENDAZOLE SULFONE; FENBENDAZOLE; OIL; FORMULATION; ANTHELMINTIC;

D O I：

10.1016/0020-7519(92)90158-H

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Pure oxfendazole (OFZ) suspended in peanut oil and the commercial formulation 'Synanthic' were each intraruminally administered to Merino weaners at 5 mg kg-1. Plasma was collected and concentrations of OFZ, fenbendazole (FBZ) and FBZ sulphone (FBZ.SO2) were determined by HPLC. The maximum concentrations and area under the plasma concentration curve (AUC) of OFZ and FBZ were significantly higher (P < 0.05) when OFZ was suspended in peanut oil than when administered as the commercial formulation.

引用

页码：541 / 543

页数：3

共 5 条

[1] THE EFFECT OF DOSE FORM ON THE BIOAVAILABILITY OF MEBENDAZOLE IN MAN [J].