MORPHOMETRIC MODEL OF NORMAL RABBIT DORSAL-ROOT GANGLIA

被引：7

作者：

MCLAIN, RF

WEINSTEIN, JN

机构：

[1] Department of Orthopaedic Surgery, University of California, Sacramento, CA, Davis

[2] Department of Orthopaedic Surgery, University of Iowa, Iowa, IA

来源：

SPINE | 1993年 / 18卷 / 13期

关键词：

DORSAL ROOT GANGLION; RABBIT; STEREOLOGY; LOW-BACK PAIN;

D O I：

10.1097/00007632-199310000-00005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The rabbit dorsal root ganglion is an important model of pain mechanisms in the human spine. A morphometric model of the normal rabbit dorsal root ganglion was constructed to provide quantitative comparisons with injured ganglia. Lumbar ganglia were studied under light and electron microscopy using simple stereologic methods. Neuronal diameter ranged from 18 to 85 mu, with 60% between 30 and 50 mu. Neurons constituted approximately 30% of dorsal root ganglion volume, and neuronal nuclei accounted for 14% of neuronal volume and 4% of dorsal root ganglion volume. Contributions from organelles to dorsal root ganglion volume were: mitochondria, 1.5%; rough endoplasmic reticulum, 9.4%; lysosomes, 0.2%; golgi, 0.5%. This morphometric model facilitates quantitative analysis of ganglia exposed to direct or indirect stimuli, providing important information on the structural changes that influence pain production.

引用

页码：1746 / 1752

页数：7

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