ABSENCE OF DETECTABLE STRIATAL DOPAMINE D-4 RECEPTORS IN DRUG-TREATED SCHIZOPHRENIA

被引：90

作者：

REYNOLDS, GP

MASON, SL

机构：

[1] Department of Biomedical Science, University of Sheffield, Sheffield

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 281卷 / 02期

关键词：

DOPAMINE D-4 RECEPTOR; SCHIZOPHRENIA; ANTIPSYCHOTIC;

D O I：

10.1016/0014-2999(95)00408-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The difference between saturable binding of [H-3]emonapride (to D-2, D-3 and D-4 receptors) and [I-125]epidepride (to D-2 and D-3 receptors) was used to determine dopamine D-4 receptors in putamen taken post-mortem from antipsychotic-treated schizophrenic subjects and matched controls. Despite an overall increase in D-2/D-3 receptor density in schizophrenia, reflecting prior antipsychotic drug treatment, striatal D-4 receptors were not significantly detectable in either controls or schizophrenic subjects.

引用

页码：R5 / R6

页数：2

共 7 条

[1] BIPHASIC DISPLACEMENT OF [H-3] YM-09151-2 BINDING IN THE RAT-BRAIN BY THIORIDAZINE, RISPERIDONE AND CLOZAPINE, BUT NOT BY OTHER ANTIPSYCHOTICS [J].