NEW EFFICIENT AND FLEXIBLE SYNTHESIS OF POLYSUBSTITUTED PYRROLES

被引：12

作者：

ENDERS, D

HAN, SH

MAASSEN, R

机构：

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 44期

关键词：

D O I：

10.1016/0040-4039(95)01717-V

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Lewis acid mediated reaction of readily available 2-acetoxypropanal-N,N-dimethylhydrazone 1 with various open chain and cyclic silyl enol ethers 2 leads directly or via 4-oxoaldehyde-N,N-dimethylhydrazones 3 to N-(dimethylamino)-pyrroles 4. The subsequent reductive N-N bond cleavage provides an efficient and flexible method for the preparation of alkyl-aryl-di- and trisubstituted pyrroles 5.

引用

页码：8007 / 8010

页数：4

共 24 条

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